Dr. Radu Silaghi-Dumitrescu

Radu Silaghi-Dumitrescu, PhD

Professor

11, Arany Janos str., room 80, 400028 Cluj-Napoca

Redox-active metalloproteins, oxidative and nitrosative stress.

 

Tel: +40 264 593 833

Email: radu.silaghi@ubbcluj.ro

Education

B.S. and M.A. in Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, 1997

PhD: in Chemistry (experimental), Department of Chemistry, University of Georgia, Athens GA (USA), 2004; in Chemistry (computational). Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, 2005

Research

Prof. Silaghi-Dumitrescu received his PhD degrees from the University of Georgia in Athens, GA, U.S.A. (2004, experimental chemistry) and from the “Babeș-Bolyai” University in Romania (2005, computational chemistry). After a postdoctoral stage at the University of Essex (Colchester, England), he returned to the “Babeș-Bolyai” University in 2007, where he teaches biochemistry, computational chemistry and related subjects, while also serving as president of the Scientific Council (2012-) and director of the Center for University Strategies (2020-). His research explores the mechanisms of redox stress in biology and medicine (especially free radicals and metals) in contexts such as blood substitutes, anticancer drugs, oxidative and nitrosative stress in various ranges of organisms (from anaerobic microorganisms to plants and to vertebrates), or plant extracts – but also interdisciplinary applications of exact science tools in scientometrics or in cultural studies.

Selected Publications

Lehene, Maria; Plesa, Diana; Ionescu-Zinca, Stefania; Iancu, Stefania D.; Leopold, Nicolae; Makarov, Sergei V.; Brânzanic,  Adrian M.V.; Silaghi-Dumitrescu, Radu. Adduct of aquacobalamin with hydrogen peroxide. Inorganic Chemistry, 2021, 60(17),  12681-12684.

Branzanic, Adrian; Ryde, Ulf; Silaghi-Dumitrescu, Radu. Why does sulfite reductase employ siroheme? Chemical Communications, 2019, 55, 14047-14049.

Dereven’kov, Ilia A.; Salnikov, Denis S.; Silaghi-Dumitrescu, Radu; Makarov, Sergei V.; Koiffman, Oscar I. Redox chemistry of cobalamin and its derivatives. Coordination Chemistry Reviews, 2016, 309, 68–83. DOI 10.1016/j.ccr.2015.11.001

Mot, Augustin; Kis, Zoltan; Svistunenko, Dimitri A.; Damian, Grigore; Makarov, Sergei V.; Silaghi-Dumitrescu, Radu. ‘Super-reduced’ iron under physiologically-relevant conditions. Dalton Transactions, 2010, 39(6):1464-6.

Silaghi-Dumitrescu, Radu. Linkage isomerism in nitrite reduction by cytochrome cd₁ nitrite reductase.  Inorganic Chemistry, 2004, 43(12), 3715-3718.

Full publication list: https://scholar.google.ro/citations?user=lJCkgfUAAAAJ&hl=ro

Courses held:

Undergraduate:

1. 1. Bioinorganic chemistry
2. Biochemistry

Graduate:

1. Advanced bioinorganic chemistry
2. Advanced biochemistry
3. Applied biochemistry
4. Computational chemistry
5. Clinical enzymology and immunology